Senior/Principal Scientist, Computational Chemistry

This is a mid sized Biotech in the Boston/Cambridge area and they are looking for a results oriented, strategic thinker to apply computational chemistry, bioinformatics, cheminformatics, and medicinal chemistry design principles to support their drug discovery programs and target identification and validation efforts.

Responsibilities:

• Computational Modeling Techniques such as Structure based and Ligand Based
• Structural bioinformatics  
• Evaluate the similarities of Targets Class
• Design of Hopping based compounds
• Chemical assessment techniques
• Prediction of physicochemical compounds
• ADME properties
• Help in design and selection of compounds
• Use Cheminformatics techniques 
• HTS analysis, library design, SAR visualization, etc.
• Develop and apply of novel computational capabilities
• FEP, protein simulations, and analysis

Experience and Skillset needed

• Must have a passion for discovering new medicines that will help to treat disease.
• A PhD in a related field.
• At least 5 years of computational chemistry experience.
• 5+ years of working in a Biotech or Pharma environment.
• Must be comfortable with the different aspects of modern computational chemistry.
• Must be able to demonstrate impact in applying computational chemistry in past roles.
• Publications and Patents must indicate your ability to drive the design/progression of compounds in a drug discovery team setting. 
• Must have worked as part of a drug discovery team that was in early through to late stage discovery.
• Must have a strong understanding of medicinal chemistry.
• Knowledge of DMPK principles, multi-parameter compound design and optimization.
• Strong interpersonal and communication skills are needed.